Cell-matrix adhesions in 3D
نویسندگان
چکیده
منابع مشابه
Components of cell-matrix adhesions.
Focal adhesions (FAs), also known as ‘focal contacts’, are specialized, extracellular matrix (ECM) attachment and signaling organelles, usually measuring a few square microns, located along the ventral plasma membrane of adherent cultured cells. Interference reflection microscopy, electron microscopy and micro-mechanical measurements indicate that the cell membrane in these sites is tightly con...
متن کاملAdvances in imaging cell-matrix adhesions.
Adhesion is fundamental to the survival and function of many different cell types, and regulates basic events such as mitosis, cell survival and migration, in both embryonic and adult organisms. Cell-matrix adhesion also regulates the dynamic interplay between cells and surrounding tissues during processes such as immune cell recruitment, wound healing and cancer cell metastasis. The study of c...
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Cell adhesion to individual macromolecules of the extracellular matrix has dramatic effects on the subcellular localization of the actin-bundling protein fascin and on the ability of cells to form stable fascin microspikes. The actin-binding activity of fascin is down-regulated by phosphorylation, and we used two differentiated cell types, C2C12 skeletal myoblasts and LLC-PK1 kidney epithelial ...
متن کاملMolecular diversity of cell-matrix adhesions.
In this study we have examined for molecular heterogeneity of cell-matrix adhesions and the involvement of actomyosin contractility in the selective recruitment of different plaque proteins. For this purpose, we have developed a novel microscopic approach for molecular morphometry, based on automatic identification of matrix adhesions, followed by quantitative immunofluorescence and morphometri...
متن کاملAutomated Analysis of Cell-Matrix Adhesions in 2D and 3D Environments
Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation, proliferation, survival, tissue morphogenesis, wound healing, and tumorigenesis. Adhesions are dynamic structures that are classically defined on two-dimensional (2D) substrates, though the need to analyze adhesions in more physiologic three-dime...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2011
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2011.06.001